History of Phosphatidylserine

Phosphatidylserine (PS), a phospholipid component critical to the structure and function of nerve cells, has a long history rooted in neuroscience research. Originally identified in the mid-19th century, PS received particular scientific interest in the 1970s and 1980s due to its association with brain health.

Traditional sources of PS were primarily bovine, but potential safety issues led to the shift towards plant-based alternatives, with soy and sunflower being the most popular.



Scientific Makeup of Phosphatidylserine

Phosphatidylserine is a phospholipid, a type of fat present in every cell of the body, but found in particularly high concentrations in the brain. PS molecules form the backbone of the cell membrane, providing structural support and playing a crucial role in cell signalling.

At the molecular level, phosphatidylserine consists of a glycerol backbone, two fatty acid chains, and a phosphate group linked to a serine molecule. Research into phosphatidylserine’s structure and function continues to elucidate its role in human health, with studies like this supporting its cognitive benefits.

Benefits of Phosphatidylserine

The potential benefits of phosphatidylserine are predominantly linked to brain health and cognitive function. Several studies indicate that PS may support memory and concentration, especially in ageing individuals. PS is believed to aid communication between brain cells, contributing to enhanced cognitive function.

Phosphatidylserine may also contribute to a healthy mood. Certain studies suggest PS can mitigate symptoms of depression and reduce perceived stress. This quality aligns phosphatidylserine with other mood-supporting supplements like St. John’s Wort or Rhodiola Rosea.

In addition, PS is also thought to improve exercise performance and post-exercise recovery by potentially mitigating muscle soreness and reducing the cortisol response to exercise-induced stress.


Safety and Dosages of Phosphatidylserine

Phosphatidylserine is generally considered safe for consumption, with few reported side effects. However, it is always recommended to consult with a healthcare professional before starting any new supplement.

The typical daily dose of PS ranges from 100mg to 500mg. Higher doses may be used under medical supervision for specific purposes. Phosphatidylserine may interact with certain medications, particularly those for Alzheimer’s disease and glaucoma, so individuals on these medications should exercise caution.


Forms of Consumption and Potential Combinations

Phosphatidylserine can be incorporated into a wide variety of supplement formats. From capsules and tablets to powders, Supplement Factory can facilitate a diverse range of delivery methods to best align with consumer preferences and enhance absorption.

PS is often combined with other brain-health-promoting ingredients such as Omega-3 fatty acids, particularly DHA and EPA, which are also essential components of the brain’s cellular structure. Other common companions include Ginkgo Biloba and Bacopa Monnieri, both renowned for their cognitive benefits.

For exercise benefits, phosphatidylserine can be combined with ingredients like Branched-Chain Amino Acids (BCAAs) or Creatine, to potentially enhance workout performance and recovery.

The versatility of PS allows for myriad combinations, offering supplement brands the chance to create unique blends that cater to the varied needs of health-conscious consumers.

If you’re considering a bespoke supplement formulation featuring phosphatidylserine, contact Supplement Factory today to explore their comprehensive supplement solutions for your brand.