History of Isoleucine

Isoleucine, one of the three branched-chain amino acids (BCAAs), has a rich history rooted in the annals of biochemistry. Discovered in the early 20th century, it was quickly recognised for its essential role in human health.

Historically, its importance was underscored when researchers found that it was indispensable for protein synthesis and muscle tissue repair.

Over the decades, as the understanding of amino acids expanded, Isoleucine’s significance in sports nutrition and general well-being became more pronounced.

Scientific Make-Up

Isoleucine is an α-amino acid with the chemical formula C₆H₁₃NO₂. It’s classified as a BCAA. These BCAAs share a unique branched structure, distinguishing them from other amino acids.

Isoleucine is chiral, meaning it has two different optical isomers, but only the L-isomer is incorporated into mammalian proteins.


Benefits of Isoleucine

Isoleucine plays a pivotal role in various physiological processes:


1. Muscle Repair and Growth: It aids in the repair of muscle tissues, making it a favourite among athletes and bodybuilders.


2. Energy Production: Isoleucine is involved in energy regulation, especially during prolonged physical activity.


3. Blood Sugar Regulation: It can assist in stabilising blood sugar levels, potentially benefiting those with metabolic concerns.


4. Haemoglobin Production: Isoleucine contributes to the formation of haemoglobin, which transports oxygen in the blood.


Forms of Consumption

Isoleucine can be consumed through various delivery methods:


1. Capsules and Tablets: A popular choice for those seeking precise dosages.


2. Powders: Often mixed in protein shakes or smoothies, offering flexibility in dosage.

3. Liquid Amino Acids: A rapidly absorbing option, ideal for pre or post-workout consumption.


4. Functional Foods: Incorporated into protein bars or other edibles, providing a convenient intake method.


Safety + Dosages

While Isoleucine is generally considered safe, it’s crucial to adhere to recommended dosages. Most studies suggest a daily intake of 10-12mg per kilogram of body weight.

However, athletes or those with specific health goals might require higher doses. It’s always prudent to consult a healthcare professional before starting any supplementation.


Use and Legality in UK, EU, US and Globally

In the UK and EU, Isoleucine, as a dietary supplement, is legal and widely available.

In the US, the FDA recognises Isoleucine as a Generally Recognised As Safe (GRAS) substance, allowing its sale and consumption.

Globally, its status can vary, but in most countries, it’s legal and accessible. However, athletes should be aware of specific sports bodies’ regulations, as excessive BCAA consumption might be flagged in doping tests. To explore collaboration opportunities or gain deeper insights, do contact us.