Indole-3-Carbinol

Origin of Ingredient

Indole-3-carbinol is naturally present in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, cauliflower, and kale. When these vegetables are chewed or cut, I3C is produced from its precursor, glucobrassicin. This compound is then absorbed and metabolized by the body, contributing to its health benefits.

History of Ingredient

The beneficial properties of cruciferous vegetables have been recognized for centuries in traditional diets and herbal medicine. Modern research into the specific compounds within these vegetables, such as indole-3-carbinol, began in the mid-20th century. Scientists discovered I3C’s role in supporting hormonal balance and studied it in relation to cancer, leading to its inclusion in dietary supplements for health and wellness.

Scientific Makeup of Ingredient

Indole-3-carbinol is a phytochemical that, upon ingestion, is converted into various bioactive compounds, including diindolylmethane (DIM). These metabolites influence several biochemical pathways, particularly those involved in estrogen metabolism. I3C has been studied in relation to enzyme activity in the liver.

Indole-3-carbinol has been studied in relation to hormone-related cancers such as breast, prostate, and cervical cancer. Studies have shown that I3C supports estrogen metabolism by promoting the production of beneficial estrogen metabolites and reducing harmful ones.

Indole-3-carbinol is widely approved for use in dietary supplements in many countries, including the United States and the European Union. Legal claims about I3C include its benefits for supporting hormone balance. Always ensure compliance with local regulatory guidelines when making specific health claims.

Health claims on food supplements in the UK and EU must be authorised, and our technical and quality team checks label wording for compliance before a label is approved.