Indole-3-Carbinol

Indole-3-carbinol (I3C) is a compound found in cruciferous vegetables like broccoli, Brussels sprouts, and cabbage, known for its potential cancer-fighting properties and support of hormone balance.

  • Bone health

  • Immune system

  • Metabolism

Origin of Ingredient

Indole-3-carbinol is naturally present in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, cauliflower, and kale. When these vegetables are chewed or cut, I3C is produced from its precursor, glucobrassicin. This compound is then absorbed and metabolized by the body, contributing to its health benefits.

History of Ingredient

The beneficial properties of cruciferous vegetables have been recognized for centuries in traditional diets and herbal medicine. Modern research into the specific compounds within these vegetables, such as indole-3-carbinol, began in the mid-20th century. Scientists discovered I3C’s role in supporting hormonal balance and reducing cancer risk, leading to its inclusion in dietary supplements for health and wellness.

Scientific Makeup of Ingredient

Indole-3-carbinol is a phytochemical that, upon ingestion, is converted into various bioactive compounds, including diindolylmethane (DIM). These metabolites influence several biochemical pathways, particularly those involved in estrogen metabolism and detoxification processes. I3C’s ability to modulate enzyme activity in the liver enhances the body’s detoxification capacity.

Research indicates that indole-3-carbinol may help reduce the risk of hormone-related cancers such as breast, prostate, and cervical cancer. Studies have shown that I3C supports estrogen metabolism by promoting the production of beneficial estrogen metabolites and reducing harmful ones. Additionally, I3C enhances detoxification processes in the liver, aiding in the elimination of toxins and potentially harmful compounds from the body.

Indole-3-carbinol is widely approved for use in dietary supplements in many countries, including the United States and the European Union. Legal claims about I3C include its benefits for supporting hormone balance, promoting detoxification, and reducing cancer risk. Always ensure compliance with local regulatory guidelines when making specific health claims.

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