AnaGain™ was developed using a bioassay-guided approach based on DNA microarray technology. AnaGain™ stimulates specific signalling molecules in the Dermal Papilla cells which are required to initiate the growth of new hair:
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During hair growth the follicles follow a cyclical and asynchronous growth phase. This cycle is made up of three distinct phases: Anagen, Catagen and Telogen. Each hair passes through the phases independently from the neighbouring hairs.
Hair loss problems, which are generally called Alopecia, often are caused by an imbalance of the hair growth cycle that leads to a reduced number of growing (Anagen) hair follicles combined with an increased number of degenerating (Telogen) hair follicles. Causes of this include hormone levels, malnutrition, environmental factors and stress. By the age of 50, at least 50% of men and approximately 25% of women are affected by hair loss.
Women experience diffuse hair loss and tend to lose the hair on the top of their heads. Meanwhile, hair loss in men can be much more extensive, mainly affecting the temporal areas and the top of the head.
The pea (Pisum Sativum) is a vegetable with pod fruits. Sprouts from organic peas were selected as a source of AnaGain™ due to their being rich in phytonutrients. These “health-promoting phytochemicals” protect the plant from disease, damage, pathogens, extreme UV, pollutants and help to defend it against herbivores.
In addition, many of these phytochemicals are known to exert positive effects on human health. Sprouts are the plant material with the highest level of phytonutrients.
The effects of AnaGain™ on hair loss were evaluated on a test panel comprising 21 volunteers suffering from mild to moderate hair loss. 100 mg of AnaGain™ was taken on a daily basis by the volunteers in a drink of their choice for a period of two months. Hair loss counts were evaluated over three days – at the beginning of the study, following one month and after two months.
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