Microcrystalline Cellulose

History of Ingredient 

Microcrystalline cellulose (MCC), a refined wood pulp derivative, has been a fundamental component in pharmaceutical and supplement manufacturing since its introduction in the 1960s. Its development marked a significant advancement in the field of excipients – substances used to enhance the properties of supplement and drug formulations.

Originating as a natural, inert, and safe additive, MCC revolutionized tablet manufacturing by improving the consistency and stability of products. Supplement Factory, a leading expert in supplement manufacturing, leverages the historical advancements of MCC to ensure high-quality and effective supplement products.

Scientific Makeup 

Microcrystalline cellulose is a highly purified, partially depolymerized cellulose. It is odorless, tasteless, and has excellent compressibility properties. MCC’s fine, crystalline structure provides essential binding and bulking qualities in tablet formulation, ensuring uniformity and consistency. 

It is insoluble in water, making it an ideal choice for oral tablets and capsules. Supplement Factory incorporates high-quality MCC in its manufacturing processes to maintain product integrity and performance.

Benefits of Ingredient 

Consistency and Stability

MCC ensures tablets and capsules have consistent quality and stability. Enhances product reliability and consumer trust. Critical for pharmaceutical and nutraceutical industries.

Enhancing Bioavailability

Improves the disintegration and dissolution of active ingredients. Boosts bioavailability and therapeutic effectiveness. Essential for effective supplement and medication formulations.

Non-Reactive Nature

Chemically inert, ensuring no reaction with active substances. Maintains the purity and efficacy of products. Safe for use in diverse pharmaceutical applications.

Ease of Processing

Facilitates easy manufacturing with its compressibility and binding qualities. Simplifies the production of tablets and capsules. Reduces manufacturing costs and complexity.


Compatible with a wide range of active ingredients. Offers flexibility in formulating various pharmaceuticals and supplements. Enables the creation of diverse dosage forms.

Safe for Consumption

Widely recognized as safe and non-toxic for human consumption. Approved by global health authorities. Trusted excipient in the supplement and pharmaceutical industries.

Forms of Consumption

Microcrystalline cellulose is primarily used in:

  • Tablet Form: Enhances the physical properties of tablets. 
  • Capsule Fillers: Acts as a filler in capsule formulations. 
  • Powder Mixes: Used in powdered supplement formulations to improve texture and flow. 
  • Chewable Tablets: Provides a desirable texture in chewable supplements. 

MCC’s role in these forms ensures optimal delivery and efficacy of supplements.

Safety + Dosages 

Regulatory bodies, including the FDA and EFSA, recognize microcrystalline cellulose as safe. As an excipient, its dosage in formulations is carefully calibrated to ensure safety and efficacy, a quality standard rigorously maintained by Supplement Factory.

Use and Legality in UK, EU, US, and Globally 

MCC is globally accepted and regulated as an excipient in the supplement and pharmaceutical industries. It complies with the regulatory standards in the UK, EU, US, and other regions, ensuring its safe and effective use in supplements. These regulations cover purity, quality, and safety, ensuring that products like those manufactured by Supplement Factory meet the highest standards.

Supplement Factory excels in integrating high-quality microcrystalline cellulose into its supplement manufacturing processes, adhering to global standards. 

For expert manufacturing solutions that include MCC, contact us.