History of NMN

Nicotinamide Mononucleotide (NMN) has garnered significant interest within the field of age-related metabolic research since the early 21st century. Its roots, however, trace back to the 1960s with the identification of nicotinamide adenine dinucleotide (NAD+) and its pivotal role in cellular processes.

NMN’s rise to prominence is closely tied to its precursor role in the synthesis of NAD+, a coenzyme essential for the function of all living cells. Notably, research in the past two decades has highlighted NMN’s potential in combating age-associated declines in NAD+ levels, positioning this compound at the forefront of longevity and wellness studies.

Scientific Makeup

NMN is a nucleotide derived from ribose and nicotinamide. Structurally, it is a ribonucleotide, which is a fundamental building block of the nucleic acid RNA. As a biosynthetic precursor to NAD+, NMN plays a critical role in cellular energy production and regulation of gene expression.

The chemical formula of NMN is C11 H15 N2 O8P, and it operates within the NAD+ salvage pathway, which recycles nicotinamide back into NAD+.


Benefits of NMN

NMN is purported to offer a multitude of health benefits, primarily related to its role in restoring NAD+ levels in the body. This restoration is believed to:

  • Enhance mitochondrial function and energy metabolism
  • Support cardiovascular health
  • Promote DNA repair and maintain genome stability
  • Improve insulin sensitivity and lipid profiles
  • Potentially delay the onset of age-related physiological decline

Research, such as studies like this, provide a scientific basis for these claims, although more extensive clinical trials are needed to fully ascertain NMN’s efficacy.


Forms of Consumption

NMN can be administered through various supplement delivery methods, each offering unique bioavailability and user convenience:


Safety + Dosages

The safety profile of NMN is favourable based on current research, with no significant adverse effects reported at common dosages. Dosage recommendations vary, but studies often utilise amounts ranging from 250 mg to 500 mg daily.

As with any supplement, it is advisable to consult healthcare professionals before commencing NMN supplementation, particularly to tailor the dose to individual health status and goals.


Use and Legality in UK, EU, US, and Globally

NMN’s legal status has undergone recent changes. In the EU and UK, NMN is categorised as a novel food, requiring pre-market authorisation. Consequently, it must meet stringent safety criteria before being included in supplements.

In the US, the FDA has recently determined that NMN is not a legal dietary supplement ingredient. This highlights the importance of continual monitoring of regulatory developments for companies like Supplement Factory, who ensure compliance with global legal standards in the production of supplements.

For further assistance or to discuss the integration of NMN into your product line, please do not hesitate to contact us.